The damaging effects of too much alcohol on the brain are widely known, but often neglected, and poorly understood. New data provided by the working group "Molecular Psychopharmacology at the Institute of Psychopharmacology at the Central Institute of Mental Health (ZI) offers a fundamentally new insight into the molecular basis by which repeated alcohol intoxication causes a substantial and long-lasting reorganization of the medial prefrontal cortex, a structure that participates in higher order brain functions, commonly referred to as executive functions.